Timely consultations relevant for family medicine, primary care, and general internal medicine topics for physicians, nurse practitioners, physician assistants, and residents. Offering CME credit for most episodes at https://ce.mayo.edu/podcast. Produced by @MayoMedEd.
Episodes
Thursday Jul 01, 2021
Thursday Jul 01, 2021
To claim credit for this episode, visit: www.ce.mayo.edu/regmedonline
Guest: Drew M. Witter, CCRP
Host: Darryl S. Chutka, M.D. (@ChutkaMD)
“Stem Cell Clinics” throughout the U.S. promote stem cell therapy for a variety of health conditions including osteoarthritis, autism, macular degeneration, Parkinson’s Disease, Alzheimer’s Disease and most recently COVID-19 infections. How can our patients be assured that the regenerative medicine therapy effectively treats their health condition and the products they receive are safe? In this podcast, we discuss regulations regarding regenerative medicine, the process of obtaining FDA-approval and which regenerative medicine therapies are FDA-approved. Our guest will be Drew Witter, a Program Manager from the Office of Research and Regulatory Support at the Mayo Clinic.
Specific topics discussed:
- Process of taking regenerative medicine from the research lab to the clinical practice
- How regulators ensure the safety and effectiveness of regenerative therapies
- The process of acquiring FDA-approval
- Regenerative medicine therapies that are FDA-approved
- How patients and clinicians learn of FDA-regulated regenerative medicine clinical trials
Additional resources:
- Clinical Trials available at Mayo Clinic through the Center for Regenerative Medicine: https://www.mayo.edu/research/centers-programs/center-regenerative-medicine/patient-care/clinical-trials
- U.S. National Library of Medicine: https://www.clinicaltrials.gov/
- Center Watch: https://www.centerwatch.com/
Additional educational opportunities from Mayo Clinic:
- https://www.mayo.edu/research/centers-programs/center-regenerative-medicine/education
- https://college.mayo.edu/academics/biomedical-research-training/phd-program/tracks/regenerative-sciences/
Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.
Thursday Jun 24, 2021
Thursday Jun 24, 2021
To claim credit for this episode, visit: www.ce.mayo.edu/regmedonline
Guest: Atta Behfar, M.D., Ph.D. (@AttaBehfar)
Host: Darryl S. Chutka, M.D. (@ChutkaMD)
Traditional treatment of cardiac disease, especially advanced congestive heart failure has been limited. Transplantation has potential for benefit; however, organ shortage remains a barrier. It’s anticipated that regenerative medicine will help solve this unmet need with new treatment options to repair damaged heart tissue. This podcast will discuss regenerative medicine for cardiovascular disease with Dr. Atta Behfar, a Mayo Clinic cardiologist with expertise in advanced heart failure and transplantation. We’ll review the progress made in regenerative medicine in management of cardiovascular disease, what treatment options are currently available and the potential treatment options which will become available in the future.
Specific topics discussed:
- Regenerative potential of the cardiovascular system
- Current challenges in management of patients with cardiovascular disease
- Progress in regenerative medicine for the cardiovascular system
- Limitations in regenerative cardiac therapy using regenerative medicine
- Future potential for regenerative medicine treatment of cardiovascular disease
- Patients who are candidates for cardiac regenerative therapies
Additional resources:
- Clinical Trials available at Mayo Clinic through the Center for Regenerative Medicine: https://www.mayo.edu/research/centers-programs/center-regenerative-medicine/patient-care/clinical-trials
- U.S. National Library of Medicine: https://www.clinicaltrials.gov/
- Center Watch: https://www.centerwatch.com/
Additional educational opportunities from Mayo Clinic:
- https://www.mayo.edu/research/centers-programs/center-regenerative-medicine/education
- https://college.mayo.edu/academics/biomedical-research-training/phd-program/tracks/regenerative-sciences/
Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.
Thursday Jun 17, 2021
Thursday Jun 17, 2021
To claim credit for this episode, visit: www.ce.mayo.edu/regmedonline
Guest: Nathan Staff, M.D. (@NathanStaffMD)
Host: Darryl S. Chutka, M.D. (@ChutkaMD)
The cells in our nervous system are extremely specialized, especially those in the brain. Unfortunately, nervous tissue does not have a great potential to regain function once it is lost. Exciting research is being done in the field of neuro-regenerative medicine which will give hope for improvement to those with chronic neurodegenerative disease or nerve damage from injury. Dr. Nathan Staff, a Mayo Clinic neurologist, joins us regarding the challenges with the current management of chronic neurodegenerative diseases and the future potential for treating such conditions as Parkinson’s Disease, Alzheimer’s Disease, ALS and other neurodegenerative disease with regenerative medicine therapies.
Specific topics discussed:
- Current research in regenerative medicine treatment for chronic neurodegenerative disease
- Currently used regenerative medicine in neurologic conditions
- New treatment options on the horizon for chronic neurodegenerative disease using regenerative medicine therapy
Additional educational opportunities from Mayo Clinic:
- https://www.mayo.edu/research/centers-programs/center-regenerative-medicine/education
- https://college.mayo.edu/academics/biomedical-research-training/phd-program/tracks/regenerative-sciences/
Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.
Thursday Jun 10, 2021
Thursday Jun 10, 2021
To claim credit for this episode, visit: www.ce.mayo.edu/regmedonline
Guest: Daniel Saris, M.D., Ph.D. (@sarisnl)
Host: Darryl S. Chutka, M.D. (@ChutkaMD)
Osteoarthritis of the knee is extremely common, and it’s estimated that 1 in 2 people are likely to develop symptomatic knee osteoarthritis in their lifetime. Its known that damaged cartilage is the precursor to osteoarthritis. Many individuals have had partial or complete meniscectomies for meniscal tears in the past and those individuals were then likely to eventually develop knee osteoarthritis. What if damaged cartilage was repaired instead of surgically removed? Could that be an effective treatment recommendation we could give to our patients to help prevent or treat osteoarthritis? Our podcast guest today is Dr. Daniel Saris and he has some fascinating information related to cartilage damage and repair using regenerative medicine techniques.
Specific topics discussed:
- How meniscal damage relates to osteoarthritis
- Ability of cartilage to repair itself when damaged
- Repairing a damaged meniscus instead of a partial or complete meniscectomy
- Specific techniques of repairing cartilage
- Success in treating patients with cartilage repair
- Future treatment options for osteoarthritis using regenerative medicine
Additional educational opportunities from Mayo Clinic:
- https://www.mayo.edu/research/centers-programs/center-regenerative-medicine/education
- https://college.mayo.edu/academics/biomedical-research-training/phd-program/tracks/regenerative-sciences/
Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.
Thursday Jun 03, 2021
Thursday Jun 03, 2021
To claim credit for this episode, visit: www.ce.mayo.edu/regmedonline
Guest: Shane A. Shapiro, M.D. (@ShaneShapiroMD)
Host: Darryl S. Chutka, M.D. (@ChutkaMD)
Musculoskeletal pain is extremely common and when severe, patients often gain significant benefit from joint replacements. However, until our patients reach the point where surgery is an option, our efforts to help patients with the chronic joint pain often leave much to be desired. A relatively new treatment approach has appeared in the past decade, musculoskeletal regenerative medicine. But does the research back up the numerous claims of benefit? This podcast will review the current treatment options available and future potential of regenerative medicine for musculoskeletal problems with Dr. Shane Shapiro, a sports medicine physician in the Department of Orthopedics at the Mayo Clinic. We’ll discuss the current regenerative products and therapies available to optimize patient outcomes, potential adverse effects of the therapies and the numerous claims by many clinicians regarding the benefit potential for regenerative medicine in musculoskeletal disease.
Specific topics discussed:
- Challenges of currently available traditional treatment for musculoskeletal conditions
- Benefits of stem cell injections for osteoarthritis
- Potential adverse effects of stem cell injections
- Currently available regenerative medicine therapies that have shown benefit to patients
- Validity of the many claims made by clinicians regarding the benefits of stem cell injections
Additional educational opportunities from Mayo Clinic:
- https://www.mayo.edu/research/centers-programs/center-regenerative-medicine/education
- https://college.mayo.edu/academics/biomedical-research-training/phd-program/tracks/regenerative-sciences/
Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.
Thursday May 27, 2021
Thursday May 27, 2021
To claim credit for this episode, visit: www.ce.mayo.edu/regmedonline
Guest: Saranya Wyles, M.D. (@SWylesMDPhD)
Host: Darryl S. Chutka, M.D. (@ChutkaMD)
Much of regenerative medicine is relatively new and some of the future treatment capabilities have the potential to significantly change the way we practice medicine. How do you educate established clinicians as well as clinicians in training regarding this new practice? How do you educate the general public which has been misled by a variety of false claims regarding which medical conditions regenerative medicine can currently effectively treat? This podcast discusses how a relatively new medical field puts together an education program to inform others of its potential. Our guest is Saranya Wyles, M.D., a resident in the Department of Dermatology who has considerable experience in regenerative medicine education.
Specific topics discussed:
- Specific groups who need educating regarding the capabilities of regenerative medicine
- The importance in training the medical workforce regarding regenerative medicine
- What regenerative medicine means for the next generation of healthcare providers
- How to incorporate regenerative medicine concepts into an established medical school curriculum
- How to educate more advanced learn years such as residents and healthcare providers
- Obtaining an advanced degree in the field a regenerative medicine
Additional resources:
- International Society for Stem Cell Research (ISSCR): https://www.isscr.org/
- The ISSCR Patient Handbook on Stem Cell Therapies: https://www.closerlookatstemcells.org/patient-resources/
- Regenerative medicine curriculum for next-generation physicians: https://www.nature.com/articles/s41536-019-0065-8
- Digital regenerative medicine and surgery pedagogy for virtual learning in the time of COVID-19: https://www.futuremedicine.com/doi/full/10.2217/rme-2020-0106
Additional educational opportunities from Mayo Clinic:
- https://www.mayo.edu/research/centers-programs/center-regenerative-medicine/education
- https://college.mayo.edu/academics/biomedical-research-training/phd-program/tracks/regenerative-sciences/
Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.
Thursday May 20, 2021
Thursday May 20, 2021
To claim credit for this episode, visit: www.ce.mayo.edu/regmedonline
Guest: Saad J. Kenderian, M.B., Ch.B. (@kenderian_ss)
Host: Darryl S. Chutka, M.D. (@ChutkaMD)
Regenerative immunotherapy is a treatment that uses the power of our own immune system to fight malignancy. It can include targeted antibodies, cancer vaccines, or tumor infecting viruses to name a few. Some immunotherapy treatments use genetic engineering to enhance our immune cell’s cancer fighting properties and can be used in combination with more traditional treatments including surgery, chemotherapy, or radiation. It’s FDA-approved as a first line treatment of multiple cancers and may also be effective in the management of malignancies that have been resistant to more traditional therapy. This podcast will address regenerative immunotherapy with Dr. Saad Kenderian, a hematologist at the Mayo Clinic. We’ll review the relationship between cancer and our immune system, how we can use our immune system to treat malignancy and which malignancies which have shown the best responses to regenerative immunotherapy.
Specific topics discussed:
- Relationship between cancer and our immune system
- How we can use our body’s immune system to fight malignancy
- Malignancies which can be currently be effectively treated with regenerative immunotherapy
- Malignancies which have had the best responses to regenerative immunotherapy
- Limitations in regenerative immunotherapy
Additional educational opportunities from Mayo Clinic:
- https://www.mayo.edu/research/centers-programs/center-regenerative-medicine/education
- https://college.mayo.edu/academics/biomedical-research-training/phd-program/tracks/regenerative-sciences/
Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.
Thursday May 13, 2021
Thursday May 13, 2021
To claim credit for this episode, visit: www.ce.mayo.edu/regmedonline
Guest: Richard E. Hayden, M.D.
Host: Darryl S. Chutka, M.D. (@ChutkaMD)
Currently reconstructive surgery involves taking the patient’s tissue from one area of their body and using it elsewhere to rebuild diseased or damaged tissue. Regenerative reconstructive surgery will allow the patient to grow their own replacement tissue from stem cells. This has incredible potential for allowing significantly better reconstructive surgical results. Currently regenerative reconstructive surgery is in its infancy, however in the next several years this should develop into a new standard of care for patients who need reconstructive surgery. This podcast features Dr. Richard Hayden, a reconstructive surgeon/otolaryngologist. We discuss the future of reconstructive surgery using regenerative medicine techniques, the difficulties in enabling patient access to regenerative therapies, the education that’s needed for not only providers but also for patients, and the future of regenerative reconstructive surgery.
Specific topics discussed:
- Role regenerative medicine plays and reconstructive surgery
- Importance in adopting and delivering regenerative care
- Challenges in current standard of care approaches in reconstructive surgery
- Difficulties enabling patient access to regenerative therapies
- Educational needs in regenerative reconstructive surgery
- The future of regenerative reconstructive surgery
Additional educational opportunities from Mayo Clinic:
- https://www.mayo.edu/research/centers-programs/center-regenerative-medicine/education
- https://college.mayo.edu/academics/biomedical-research-training/phd-program/tracks/regenerative-sciences/
Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.
Thursday May 06, 2021
Thursday May 06, 2021
To claim credit for this episode, visit: www.ce.mayo.edu/regmedonline
Guest: Dennis Wigle, M.D., Ph.D. (@DrWigle)
Host: Darryl S. Chutka, M.D. (@ChutkaMD)
Regenerative Medicine has some amazing capabilities and in the near future, it’s likely to significantly change how we practice medicine. It faces some challenges in educating both the medical community as well as the general public regarding its current realistic capabilities. There are many unsubstantiated claims made by practitioners to the public regarding the benefits of regenerative medicine therapy. We’ll discuss how the true potential of regenerative medicine is conveyed to both clinicians and the public with Dr. Dennis Wigle, a thoracic surgeon and chair of the Division of General Thoracic Surgery at the Mayo Clinic. We’ll discuss some of the common misperceptions of regenerative medicine and how a consultation service can educate both the public and medical community regarding the benefits of regenerative medicine.
Specific topics discussed:
- How to provide education to the public and the medical community
- When and why the regenerative consultation service was formed
- How the regenerative medicine consultation service works
- Common misperceptions community regarding the realistic benefits of regenerative medicine
Additional resources:
- For more information about Mayo Clinic’s Regenerative Medicine Consult Service, visit: https://www.mayo.edu/research/centers-programs/center-regenerative-medicine/patient-care/regenerative-medicine-consult-service
Additional educational opportunities from Mayo Clinic:
- https://www.mayo.edu/research/centers-programs/center-regenerative-medicine/education
- https://college.mayo.edu/academics/biomedical-research-training/phd-program/tracks/regenerative-sciences/
Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.
Tuesday May 04, 2021
Tuesday May 04, 2021
To claim credit for this episode, visit: www.ce.mayo.edu/regmedonline
Guest: Fredric B. Meyer, M.D.; Andre Terzic, M.D., Ph.D.
Host: Darryl S. Chutka, M.D. (@ChutkaMD)
Imagine a patient who has suffered a massive myocardial infarction leaving a significant amount of damaged and non-functioning ventricular myocardium. Treatment for this patient’s subsequent congestive failure does not involve diuretics and beta blockers but rather an injection of the patient’s modified stem cells into surrounding viable ventricular myocardium resulting in the regeneration of new, functioning myocardial cells restoring the cardiac output. This is not science fiction but represents ongoing work by investigators in Regenerative Medicine. This week’s podcast will explore this amazing field of medicine which has the potential to change how medicine is practiced. We’ll discuss the origins of regenerative medicine, what currently be done in regenerative medicine as well as the potential for the future. Our guests today are Andre Terzic, M.D., Ph.D., director of the Mayo Clinic Center for Regenerative Medicine and Fredric B. Meyer, M.D., a neurosurgeon and the Executive Dean for Education at the Mayo Clinic.
Specific topics discussed:
- When the field of regenerative medicine began
- Which current medical conditions can currently be managed with regenerative medicine
- How to determine which patients have potential for regenerative medicine therapies
Additional educational opportunities from Mayo Clinic:
- https://www.mayo.edu/research/centers-programs/center-regenerative-medicine/education
- https://college.mayo.edu/academics/biomedical-research-training/phd-program/tracks/regenerative-sciences/
Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.